Abcam, ab34752, Anti-Parainfluenza Virus type 1 nucleocapsid antibody [7F5]

Size: 100µL
Mouse Monoclonal Parainfluenza Virus type 1 nucleocapsid antibody. Suitable for WB, ELISA and reacts with Recombinant full length protein - Human respirovirus 1 samples. Cited in 2 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:7F5,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human respirovirus 1,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody reacts with nucleocapsid protein of human parainfluenza virus type 1 (hPIV-1). It does not cross-react with nucleocapsid proteins of Sendai virus and human parainfluenza virus type 3 (hPIV-3), neither does it react with nucleocapsid proteins of measles, mumps, Menangle, Nipah, and Hendra viruses.

Properties and Storage Information:
Form-Liquid, Purity-IgG fraction, Storage buffer-pH: 7.2 - 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Parainfluenza Virus type 1 nucleocapsid often called 'hPIV-1 nucleocapsid' plays an important role in viral replication and transcription. This protein has a mass of approximately 55 kDa and is expressed in host cells post-infection. It is responsible for encapsidating the viral RNA genome forming the helical nucleocapsid structure which is essential for protecting the RNA and serving as a template for replication and transcription. The nucleocapsid interacts with the phosphoprotein to facilitate these processes ensuring precise and efficient viral propagation.
Biological function summary
The nucleocapsid serves as a multifunctional element important for the life cycle of the virus. It is part of a larger ribonucleoprotein complex that involves interactions with additional viral proteins such as the polymerase. This assembly aids the virus in efficiently hijacking the host cell system to replicate its genome and produce viral progeny. The nucleocapsid's interactions make it possible for the virus to maintain the integrity of its RNA ensuring effective viral replication and infection spread within the host.
Pathways
The nucleocapsid's functions significantly impact the viral replication and transcription pathways. The complex formation with the phosphoprotein and the polymerase is essential for the RNA replication machinery promoting viral RNA synthesis. The nucleocapsid contributes to the uninterrupted progression of the viral replication cycle sealing its importance in sustaining the virus's life cycle within the host environment. The pathways involving these interactions are critical for the virus's ability to propagate and evade host defenses.
The hPIV-1 nucleocapsid protein is closely linked to respiratory infections. These infections can lead to conditions such as croup and bronchiolitis mainly affecting infants and young children. The nucleocapsid's interaction with other viral proteins like the matrix protein plays a substantial role in pathogenesis by influencing viral assembly and budding. Understanding these associations strengthens the potential to develop targeted antiviral therapies focusing on modulating these interactions to alleviate or prevent parainfluenza-related diseases.