Abcam, ab3530, Anti-Calcium Pump PMCA3 ATPase antibody

Size: 100µg
Rabbit Polyclonal Calcium Pump PMCA3 ATPase antibody. Suitable for IHC, IHC-P and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Detects PMCA 3a and 3b ATPase.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Calcium Pump PMCA3 ATPase also known as Plasma Membrane Calcium-Transporting ATPase 3 plays an important role in calcium homeostasis. This enzyme weighing approximately 134 kDa actively transports calcium ions out of cells to maintain low intracellular calcium levels. PMCA3 is mainly expressed in the brain and other neural tissues where it helps regulate neuronal signaling. The pump uses ATP to move calcium against its concentration gradient from the cytosol to the extracellular space a critical function for cellular activities.
Biological function summary
PMCA3 controls the concentration of cytosolic calcium ions which influences many cellular processes such as muscle contraction neurotransmitter release and gene expression. PMCA3 often functions independently although it can sometimes exist in complexes with other proteins influencing its regulation and activity. The regulation of neuronal calcium levels through PMCA3 is essential for proper synaptic function and plasticity making it a point of interest in neurophysiological research.
Pathways
PMCA3 plays a role in the calcium signaling pathway affecting signal transduction processes across various cell types. It acts alongside other calcium-handling proteins including Ca2+ channels and buffers in modulating cellular responses to physiological stimuli. Additionally PMCA3 intersects with the MAPK signaling pathway by influencing intracellular calcium which in turn can activate protein kinases and affect transcription regulation.
PMCA3 holds relevance in conditions such as spinocerebellar ataxia and epilepsy. Mutations or dysregulation of PMCA3 can disrupt calcium homeostasis leading to neurodegenerative conditions such as ataxia where coordination and balance are impaired. The dysregulated calcium flow can also influence seizure activity in epilepsy by affecting neurons' excitability. Associations with proteins like calmodulin which regulates PMCA3 activity further elucidate its pathophysiological connections in these diseases.