Abcam, ab36855, Anti-TTC5 antibody

Size: 100µg
Rabbit Polyclonal TTC5 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Tetratricopeptide repeat protein 5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Tetratricopeptide repeat protein 5. The exact immunogen used to generate this antibody is proprietary information.Q8N0Z6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TTC5 also known as Tetratricopeptide Repeat Domain 5 functions mechanically as a cochaperone involved in protein folding and stabilization. This protein has a molecular mass of approximately 61 kDa. It is detected in various tissues with higher expression levels in tissues like the brain and heart suggesting tissue-specific roles. TTC5 contains several tetratricopeptide repeat (TPR) motifs that facilitate protein-protein interactions necessary for its function.
Biological function summary
TTC5 participates in regulating transcriptional processes. It is a component of protein complexes that interact with transcription factors and other regulatory proteins to influence gene expression. TTC5 helps in modulating the activity of p53 a major tumor suppressor protein as part of its role in transcriptional regulation. By assisting in stress response mechanisms TTC5 contributes to maintaining cellular homeostasis.
Pathways
TTC5 plays roles in key cellular resultants like the p53 signaling pathway and the heat shock response pathway. In these pathways TTC5 works with proteins such as HSP90 and cochaperones to ensure correct protein conformation under stress conditions. The interaction with p53 highlights its importance in checkpoint control and apoptosis ensuring proper cell cycle progression and response to DNA damage.
Research links TTC5 to cancer and neurodegenerative diseases. Its role in modulating p53 activity connects it to tumorigenesis as impaired function could lead to reduced tumor suppression. Also in neurodegenerative conditions mutations or dysregulation of TTC5 may alter stress response pathways. This disruption potentially influences networks involving proteins like p53 and HSP90 contributing to disease progression.