Abcam, ab36870, Anti-CTRP3 antibody

Size: 100µg
Rabbit Polyclonal CTRP3 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human C1QTNF3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human C1QTNF3. The exact immunogen used to generate this antibody is proprietary information.Q9BXJ4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTRP3 also known as C1q/TNF-related protein 3 or Cartducin is a secreted protein with a molecular mass of approximately 25 kDa. This protein expresses in various tissues including adipose tissue liver and cartilage. The presence of CTRP3 in these diverse tissues suggests its involvement in various physiological processes. As a member of the CTRP family CTRP3 shares a conserved C1q domain which indicates potential functional similarities with other family members.
Biological function summary
The activity of CTRP3 impacts metabolic regulation and anti-inflammatory responses. Its action is not associated directly with a complex but it interacts with multiple signaling molecules and pathways. In adipocytes CTRP3 decreases glucose output and enhances insulin signaling. It also possesses anti-inflammatory properties by downregulating pro-inflammatory cytokines contributing to an overall reduced inflammatory state. These biological activities make CTRP3 a significant protein in metabolic homeostasis and immune response modulation.
Pathways
CTRP3 influences several mechanisms such as the insulin signaling pathway and the NF-kB signaling pathway. By interacting with proteins like Akt and AMPK within the insulin pathway CTRP3 enhances glucose uptake and utilization. It also modulates NF-kB activity suppressing inflammatory responses suggesting a protective role against chronic inflammation. These actions demonstrate CTRP3’s integration into important systems that coordinate metabolic health and immune function.
CTRP3 has connections to metabolic syndrome and osteoarthritis. Its role in metabolic regulation ties it with insulin resistance a core feature of metabolic syndrome. CTRP3 improves insulin sensitivity potentially mitigating associated disorders. In osteoarthritis its anti-inflammatory effect can influence disease progression by reducing inflammation in joint tissues. Proteins such as adiponectin and leptin are involved in these contexts with CTRP3 interacting functionally with them suggesting possible therapeutic targets for managing disease conditions linked to metabolic and inflammatory dysregulation.