Abcam, ab38905, HRP Anti-Plasmodium aldolase antibody

Size: 250µg
Rabbit Polyclonal ALF antibody - conjugated to HRP. Suitable for ELISA, WB and reacts with Plasmodium falciparum samples. Cited in 26 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Conjugation:HRP,
Carrier free:No,
Reacts with:Plasmodium falciparum,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 1.19% HEPES, 0.58% Sodium chloride, 0.2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Plasmodium aldolase also known as ALD or aldolase MW is an important enzyme in the glycolytic pathway. It has a molecular weight of approximately 39 kDa. The enzyme catalyzes the reversible cleavage of fructose-16-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This reaction is important for energy production in the parasite Plasmodium which causes malaria. Plasmodium aldolase is expressed in various stages of the parasite's life cycle including the erythrocytic stage where the parasite infects red blood cells.
Biological function summary
Plasmodium aldolase plays a significant role in the survival and replication of the malaria parasite. It is not part of a larger protein complex but often associates with the cytoskeleton within the parasite facilitating its structural integrity and mobility. The enzyme's activity directly impacts the energy metabolism of Plasmodium making it essential for parasite survival and development in the host.
Pathways
Enzymes like Plasmodium aldolase operate within glycolytic and gluconeogenic pathways which are central to carbohydrate metabolism. In the glycolytic pathway aldolase sequentially interacts with proteins such as glyceraldehyde-3-phosphate dehydrogenase. Through its function in energy production aldolase indirectly supports various biosynthetic reactions and parasitic replication processes specific to Plasmodium.
Disturbances in Plasmodium aldolase function are directly linked to malaria one of the major global infectious diseases. The enzyme itself is a target for antimalarial drug development as inhibitors could potentially disrupt parasite energy metabolism leading to its death. Research also indicates a connection between aldolase and another protein lactate dehydrogenase which facilitates the parasite's anaerobic metabolism thereby contributing to its adaptability under different oxygen conditions in the human host.