Abcam, ab3924, Anti-IgA Secretory Component antibody [SC-05]

Size: 100µg
Anti-IgA Secretory Component antibody [SC-05] (ab3924) is a mouse monoclonal antibody detecting IgA Secretory Component in Western Blot . Suitable for Human . - Over 10 publications - Trusted since 2003
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SC-05,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab3924 reacts with 80 kDa human secretory component glycoprotein (both free and bound in secretory IgA). The recognized glycoprotein is a specific membrane marker of glandular carcinomas.

Product details:
What is this antibody validated in?
Anti-IgA Secretory Component antibody [SC-05] (ab3924) is a mouse monoclonal antibody and is validated for use in Western Blot (WB) in Human samples.
What is the molecular weight of IgA Secretory Component?
Anti-IgA Secretory Component [SC-05] (ab3924) specifically detects a band for IgA Secretory Component (UniProt: Q16610) at a molecular weight of 61kDa.
Trusted by the scientific community
Anti-IgA Secretory Component [SC-05] (ab3924) was first used in a scientific publication in 2003 and has been cited over 10 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified from hybridoma culture supernatant. Purity >95% by SDS-PAGE., Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The IgA Secretory Component often referred to as IgA SC or Anti-Secretory is an important segment of the polymeric immunoglobulin receptor (pIgR) with a mass around 83 kDa. It is primarily expressed on epithelial cells where it plays a role in mucosal immunity. This component facilitates the transcytosis of polymeric IgA antibodies across epithelial layers and plays an important role in the secretion of IgA into mucosal networks. Due to its mechanism of action the Secretory Component ensures that IgA antibodies reach the mucosal surface where they help in neutralizing pathogens and toxins.
Biological function summary
The IgA Secretory Component is essential in forming a complex with polymeric IgA to create Secretory IgA (SIgA). This complex is integral to mucosal surfaces such as the respiratory gastrointestinal and urogenital tracts providing a defense mechanism against environmental pathogens. The association between IgA SC and polymeric IgA confers stability and protection to the IgA dimers from proteolytic enzymes ensuring their functional role in local immunological responses at mucosal sites.
Pathways
IgA Secretory Component is involved in pathways for mucosal immunity and IgA antibody transport. It interacts with proteins related to the immune response including J-chain which binds to the polymeric IgA facilitating its binding to the pIgR. This interaction denotes a critical step in the active transport and subsequent secretion of SIgA at epithelial surfaces which are vital in immunological defense mechanisms.
IgA Secretory Component is linked to conditions such as selective IgA deficiency and inflammatory bowel disease (IBD). In selective IgA deficiency where there is a lack or reduced levels of IgA dysfunction in IgA SC may disrupt mucosal immunity. In inflammatory bowel disease improper regulation or expression of the IgA SC plays a role impacting the protective SIgA along the gut mucosa. Such conditions show connections to other proteins within the immune system like cytokines that influence inflammatory responses and immune regulation at the mucosal barriers.