Abcam, ab39350, Anti-Plexin A4 antibody

Size: 100µg
Rabbit Polyclonal Plexin A4 antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 15 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From July 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Plexin A4 also known as PLXNA4 is a protein with a mass of approximately 220 kDa. It functions as a receptor for semaphorin proteins which play an important role in guiding axon pathways during neural development. Plexin A4 binds to its semaphorin ligands and initiates signal transduction resulting in growth cone collapse and axonal growth direction changes. It is highly expressed in the central nervous system particularly in the brain and the spinal cord.
Biological function summary
Plexin A4 facilitates axonal pathfinding and neuronal network formation by interacting with semaphorin ligands and it often functions as part of a receptor complex. The receptor complex typically involves neuropilins which binds to semaphorins with higher affinity and subsequently recruits Plexin A4 for signal transduction. This signaling regulates not only neural development but also plays roles in immune response modulation and vascular development.
Pathways
Plexin A4 engages in semaphorin-plexin signaling and contributes significantly to axonal guidance pathways. It forms part of a signaling cascade with proteins like the neuropilins and other members of the plexin family orchestrating neuronal connectivity. Additionally it interacts with the Rho family of GTPases such as RhoA and Rac1 which are underlying signaling molecules that regulate cytoskeletal dynamics essential for cell migration and morphogenesis.
Disrupted Plexin A4 function associates with neurological conditions like autism spectrum disorders and neurodegenerative diseases. Aberrant Plexin A4 signaling impacts neuronal circuity leading to such disorders. Additionally its involvement in the immune response connects Plexin A4 to autoimmune diseases where dysregulation may contribute to pathogenesis. It often work alongside proteins like semaphorin 3A and neuropilins that are similarly implicated in these disorders.