Abcam, ab3942, Anti-TRIM2 antibody

Size: 100µg
Goat Polyclonal TRIM2 antibody. Suitable for IHC-P, WB and reacts with Human, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TRIM2 aa 700 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRIM2 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9C040

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 0.5% BSA, 0.5% Tris, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM2 also known as tripartite motif-containing protein 2 is a protein that plays an essential role in protein ubiquitination. It has a molecular mass of approximately 75 kDa. TRIM2 is mainly found in neurons and has expression profiles in the brain and other neural tissues. The protein contains a RING-type zinc finger domain that facilitates its E3 ubiquitin ligase activity enabling it to tag specific proteins for degradation by the proteasome system.
Biological function summary
TRIM2 functions by modulating the stability of specific proteins involved in neuronal growth and maintenance. It operates as part of ubiquitination complexes allowing for targeted protein degradation. Neurodevelopmental processes rely on TRIM2 activity to maintain cellular homeostasis. Its involvement in axonal transport and stabilization of microtubule-associated proteins underlines its important role in nervous system integrity and functionality.
Pathways
TRIM2's function integrates into the ubiquitin-proteasome pathway and neural development processes. Within the ubiquitin-proteasome pathway TRIM2 interacts closely with other E3 ligases and substrates essential for proper cell functioning. It also relates to the Neurotrophin TRK receptor signaling pathway where TRIM2 can influence neuronal survival and differentiation. These pathways connect TRIM2 to proteins like TRK receptors and other ligases that manage protein turnover and neuronal signaling.
Disrupted TRIM2 function associates with neurological conditions such as Charcot-Marie-Tooth disease and neurodegenerative disorders. Mutations in TRIM2 lead to impaired ubiquitination activities contributing to these diseases' progression. TRIM2 dysfunction also links to abnormalities in proteins like neurofilament light chain which further aggravate disease pathology by destabilizing neuronal architectures and interrupting normal neural processes.