Abcam, ab39716, Anti-Hepatitis B Virus X antigen antibody

Size: 50µg
Anti-Hepatitis B Virus X antigen antibody (ab39716) is a rabbit polyclonal antibody detecting Hepatitis B Virus X antigen in Western Blot, IP, ELISA . Suitable for Hepatitis B virus . - Over 30 publications - Trusted since 2006
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Hepatitis B virus,
Applications:ELISA, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:The amino acid sequence of the recombinant human Hepatitis B Protein X is 100% homologous to the amino acid sequence of the natural Hepatitis B Protein X.

Product details:
What is this antibody validated in?
Anti-Hepatitis B Virus X antigen antibody (ab39716) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), ELISA in Hepatitis B virus samples.
What is the molecular weight of Hepatitis B Virus X antigen?
Anti-Hepatitis B Virus X antigen (ab39716) specifically detects a band for Hepatitis B Virus X antigen (UniProt: P12936) at a molecular weight of 17kDa.
Trusted by the scientific community
Anti-Hepatitis B Virus X antigen (ab39716) was first used in a scientific publication in 2006 and has been cited over 30 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Constituents: PBS, 0.58% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Hepatitis B Virus X antigen also known as HBx protein or hepatitis X has a molecular mass of approximately 17 kDa. This antigen is expressed in liver cells or hepatocytes infected with the hepatitis B virus (HBV). HBx protein plays an important role in the replication and pathogenesis of HBV influencing the virus lifecycle and its ability to cause liver disease. Additionally anti-HBx antibodies such as 'anti HBx' and '3f6' are significant for research and diagnostic purposes due to their binding specificity.
Biological function summary
The function of HBx protein is to modulate various cellular processes to benefit the virus. HBx is not part of a larger protein complex but it interacts with host cell pathways to promote viral replication and survival. It influences transcriptional activation cell cycle progression and apoptosis. By hijacking the host cellular machinery HBx protein enhances viral replication and contributes to chronic infection.
Pathways
The activity of HBx protein impacts critical cellular signaling networks. HBx can activate the NF-kB signaling pathway which plays a role in immune response and inflammation. Additionally HBx influences the Wnt/Β-catenin signaling pathway affecting cell proliferation and differentiation. Through these pathways HBx interacts with multiple other proteins including c-Myc and p53 impacting cellular homeostasis and contributing to oncogenic potential.
HBx protein is associated with hepatitis B-related liver diseases and the development of hepatocellular carcinoma (HCC). HBx contributes significantly to the progression from chronic hepatitis B infection to liver cirrhosis and HCC. The protein affects tumor suppressors like p53 further enhancing its role in carcinogenesis. Understanding HBx’s mechanisms continues to be important for developing therapeutics and diagnostics aimed at treating HBV-related diseases.