Abcam, ab41525, Anti-Glucose Transporter GLUT3 antibody

Size: 100µg
Rabbit Polyclonal Glucose Transporter GLUT3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 80 publications. Immunogen corresponding to Synthetic Peptide within Mouse Slc2a3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Slc2a3. The exact immunogen used to generate this antibody is proprietary information.P32037

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-sepharose affinity column., Storage buffer-Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Glucose Transporter GLUT3 also known as GLUT-3 or SLC2A3 serves as an important protein in glucose transport across cell membranes. It is part of the facilitative glucose transporter family and exhibits a molecular weight of approximately 54 kDa. This transporter shows high affinity for glucose making it particularly important in cells with high demands for glucose. You mainly find GLUT3 expressed in brain neurons placenta and sperm where it ensures sufficient glucose uptake to sustain energy-intensive activities.
Biological function summary
The transporter protein mediates the rapid uptake of glucose into cells especially under low glucose concentrations supporting high cellular metabolic rates. It does not function alone but collaborates in transporting glucose to meet cellular needs efficiently. Although GLUT3 operates as a specific transporter it is involved in a larger network that ensures glucose availability for vital cellular processes ensuring that cells like neurons maintain function even under varying glucose availability.
Pathways
The transporter plays an integral role in the glycolysis and cellular respiration pathways. It acts in concert with other glucose transporters such as GLUT1 and GLUT4 which also facilitate glucose uptake into various cells allowing efficient energy production. The proper function of glycolysis heavily depends on the effective operation of glucose transporters where GLUT3's high affinity for glucose supports metabolic activities specifically in neural cells which relies on glucose as a primary energy source.
Several studies link GLUT3 to conditions like Alzheimer's disease and Type 2 diabetes. In Alzheimer's impaired glucose metabolism in the brain partly due to dysfunctional GLUT3 contributes to neurodegenerative processes. Similarly altered expression of GLUT3 affects glucose homeostasis playing a part in Type 2 diabetes pathophysiology alongside proteins like insulin receptors and other glucose transporters. These associations underline the significance of maintaining GLUT3 function for cellular glucose management and metabolic health.