Abcam, ab41651, Anti-Japanese encephalitis virus NS1 glycoprotein antibody [MV12/2/A5-1/6]

Size: 1mL
Mouse Monoclonal POLG antibody. Suitable for Flow Cyt, ELISA, WB, IHC-FoFr, ICC/IF and reacts with Japanese encephalitis virus samples. Cited in 10 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:MV12/2/A5-1/6,
Isotype:IgG3,
Light chain type:kappa,
Carrier free:No,
Reacts with:Japanese encephalitis virus,
Applications:IHC-FoFr, ICC/IF, WB, Flow Cyt, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.1% Proclin 150Constituents: 89.9% RPMI 1640, 10% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Japanese encephalitis virus NS1 glycoprotein also known as NS1 is an important non-structural protein in the lifecycle of the Japanese encephalitis virus. It has a molecular mass of approximately 46 kDa and is expressed in both the infected host cells and the virus itself. NS1 plays an important role in viral replication and immune evasion making it a significant focus of research. It is expressed on the surface of infected cells as a dimer or can be secreted as a hexamer providing multiple functional roles and making it a target for antibody development.
Biological function summary
The NS1 glycoprotein participates in the virus's evasion of the host's immune system. It doesn't operate as part of a complex but serves several independent functions. NS1 helps inhibit the host's complement system reducing the immune-mediated damage to the virus-infected cells. Additionally it assists in viral RNA synthesis by enhancing the efficiency of the viral replication complex supporting the production of new viral particles within the infected cell environment.
Pathways
The NS1 glycoprotein interacts with several host cell mechanisms to modulate the immune response. Specifically it is involved in the complement inhibition and RNA synthesis pathways. In the complement inhibition pathway NS1 plays a part by binding to host complement proteins impeding their function and providing an advantage to the virus against the host immune defense. Its association with the viral RNA synthesis pathway is essential for the replication of the Japanese encephalitis virus coordinating with other non-structural proteins like NS3 to ensure effective viral proliferation.
NS1 is closely linked to the pathogenesis of Japanese encephalitis and other flavivirus-related conditions. The protein's interaction with host immune responses directly correlates with the severity of these diseases by contributing to immune evasion and facilitating virus spread within the host. Additionally NS1 has been observed to share functional similarities with proteins of other viruses including dengue virus NS1 which plays a similar role in disrupting immune pathways and aiding in viral replication. Understanding these connections helps in developing effective strategies for therapeutic interventions against flaviviruses.