Abcam, ab41696, Anti-Dengue Virus E glycoprotein antibody [DE2]

Size: 1mL
Mouse Monoclonal POLG antibody. Suitable for ELISA, ICC/IF and reacts with Dengue virus 1, Dengue virus 2, Dengue virus 3, Dengue virus 4 samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Dengue Virus E glycoprotein protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:DE2,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Dengue virus 1, Dengue virus 2, Dengue virus 3, Dengue virus 4,
Applications:ICC/IF, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.1% Proclin 150Constituents: 89.9% RPMI 1640, 10% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Dengue Virus E glycoprotein also known as the envelope protein or DENV envelope protein plays an important role in the viral lifecycle. With an approximate mass of 53 kDa this protein is expressed on the surface of the Dengue Virus. It facilitates viral binding and entry into host cells by mediating the fusion process with host cell membranes. The E glycoprotein contains structural domains critical for its function including a dimeric ectodomain that undergoes conformational changes essential for viral entry. This protein is the primary target for neutralizing antibodies known as anti-dengue antibodies due to its significant role in host interaction.
Biological function summary
The Dengue Virus E glycoprotein contributes to the virus's ability to infect and replicate in host cells. It forms a homodimer complex in the viral membrane and is involved in receptor binding and membrane fusion coordinating these functions with its co-factor prM protein. This protein participates in the viral assembly process where it helps in packaging and releasing new viral particles. The interaction with host cell receptors triggers fusion activity which is an important step for the virus's successful replication and spread within the host organism.
Pathways
Dengue Virus E glycoprotein is integrated into the viral entry and replication pathways within the host. It plays a role in the flavivirus lifecycle a process critical for both infection and propagation of Dengue virus. The E glycoprotein is linked to other viral proteins like the NS1 protein that further influence viral replication and immune evasion. By engaging with endosomal pathways in the host cell it leads to productive viral infections and contributes to the viral immune evasion mechanisms.
The Dengue Virus E glycoprotein is strongly linked to Dengue Fever and Dengue Hemorrhagic Fever caused by the Dengue virus. Its role in pathogenesis stems from its function in viral entry and immune system interaction making it a principal target for vaccine development and therapeutic interventions. The NS1 protein also connects to these diseases acting in concert with the E glycoprotein to modulate pathogenicity and immune responses in the infected host. Understanding E glycoprotein function can aid in developing effective anti-dengue strategies.