Abcam, ab41974, Anti-SALL1 antibody [K9814]

Size: 100µL
Mouse Monoclonal SALL1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SALL1 aa 250-500.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:K9814,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SALL1 aa 250-500. The exact immunogen used to generate this antibody is proprietary information.Q9NSC2

Product details:
This product was changed from ascites to tissue culture supernatant on 3
April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SALL1 also known as Sal-like protein 1 is a zinc-finger transcription factor involved in the regulation of gene expression. It has a mass of about 132 kDa and is expressed in many tissues during embryonic development including the kidney brain and limb buds. SALL1 contains multiple zinc finger domains which help it bind to DNA and control the transcription of target genes.
Biological function summary
SALL1 plays an important role in the maintenance of stem cell pluripotency and tissue differentiation. It is not known for being part of any complex but interacts with other transcription factors to regulate the expression of genes necessary for normal development. Disruption in the function of SALL1 can lead to developmental defects due to improper gene regulation.
Pathways
SALL1 is involved in the Wnt signaling pathway important for developmental processes and cell fate determination. In this pathway it interacts with proteins such as β-catenin to influence cell behavior. SALL1 is also associated with the Hedgehog signaling pathway which helps in patterning and growth during embryogenesis. Through these interactions SALL1 helps coordinate complex genetic programs necessary for organismal development.
Alterations in SALL1 function are linked to Townes-Brocks syndrome a genetic condition characterized by limb ear and renal anomalies. Mutations in the SALL1 gene disrupt its ability to regulate developmental genes and lead to the phenotypic manifestations of the syndrome. Additionally SALL1 disruptions can associate with renal cancer possibly through interactions with other transcription factors like p53 which play a role in tumor suppression.