Abcam, ab4212, FITC Anti-C3c antibody

Size: 500µL
Rabbit Polyclonal C3 antibody - conjugated to FITC. Suitable for ICC/IF and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human C3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Conjugation:FITC,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human C3.P01024,
Specificity:This antibody reacts with human C3c complement and with the C3c part of C3 and C3b.

Properties and Storage Information:
Form-Liquid, Purity-IgG fraction, Purification notes-Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins., Storage buffer-Preservative: 0.05% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The C3c fragment is part of the complement system which plays an important role in the innate immune system. C3c also known as complement component 3c forms when C3 undergoes cleavage. The molecular mass of C3c ranges from approximately 135 to 186 kDa depending on the level of cleavage. It presents primarily in plasma and serum being part of the larger C3 molecule which is produced by the liver. Within tissues C3c can also appear in inflammatory sites where complement activation occurs.
Biological function summary
C3c functions as a by-product of complement activation and is associated with immune defense processes. It does not independently participate in the formation of the complement complex but results from the breakdown of C3 into C3b and other fragments. This fragment may play roles in modulating immune responses through its interaction with complement receptors. The presence of C3c marks the location and intensity of complement activation in tissue or circulation indirectly indicating the body's response to pathogens or damaged cells.
Pathways
The C3c fragment serves as an indirect marker within the complement cascade particularly signaling the involvement of the classical and alternative complement pathways. The generation of C3c follows the activation of these pathways highlighting the initial activation of C3 into active fragments such as C3b. Proteins related to these pathways include factors H and I which regulate C3b breakdown ensuring controlled progression of this immune response.
C3c levels offer insights into pathological conditions like systemic lupus erythematosus (SLE) and glomerulonephritis. Elevated levels of C3c in serum may indicate excessive complement activation and consumption often observed in these diseases. The association of C3c with disease is often mediated through its precursor C3 with abnormal C3 activation linked to tissue damage in autoimmune conditions. Proteins like C4 and complement receptor (CR1) may also connect to these disorders as they interact in pathways leading to inflammatory responses characterized by complement activity.