Abcam, ab42124, Anti-Fumonisin antibody [2A2]

Size: 100µg
Mouse Monoclonal Fumonisin antibody. Suitable for ELISA and reacts with Fusarium verticillioides samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Fumonisin.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2A2,
Isotype:IgG1,
Light chain type:lambda,
Carrier free:No,
Reacts with:Fusarium verticillioides,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Fumonisin particularly fumonisin B1 is a mycotoxin produced by certain Fusarium species notably Fusarium verticillioides. It has a molecular mass around 721 g/mol. This toxic compound is expressed primarily in contaminated agricultural commodities especially maize and maize-based products. Fumonisin acts mechanically by inhibiting the enzyme ceramide synthase which is important in sphingolipid metabolism resulting in accumulation of sphinganine and disruption of cellular processes.
Biological function summary
Sphingolipid metabolism plays an important role in cell membrane integrity and signaling processes. Fumonisin is not part of a multiprotein complex but has a significant impact on sphingolipid biosynthesis pathways. The interruption of these pathways can lead to deregulation of cell growth differentiation and programmed cell death emphasizing the biological role of fumonisin in cell regulation.
Pathways
Ceramide synthase inhibition by fumonisin disrupts the sphingolipid metabolism pathway. This pathway is essential for maintaining cellular homeostasis and is closely related to signaling pathways involving proteins such as serine palmitoyltransferase and sphingomyelin synthase. Fumonisin’s interference in these pathways can affect downstream effects in complex biological systems.
Fumonisin exposure has connections with diseases such as esophageal cancer and neural tube defects. The disruption of sphingolipid metabolism due to interfered ceramide synthase function associates fumonisin with these pathologies. In particular the modulation of proteins like folate receptor and enzymes in folate metabolism may contribute to neural defects while other alterations in cellular mechanisms relate to carcinogenesis.