Abcam, ab42806, Anti-VEZT antibody

Size: 200µL
Rabbit Polyclonal VEZT antibody. Suitable for IP, ELISA, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human VEZT.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human VEZT.Q9HBM0,
Specificity:This antibody reacts specificly with vezatin protein

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
VEZT also known as vezatin is a membrane-associated molecule that plays significant mechanical roles within cells. It has an approximate mass of 85 kDa. VEZT is widely expressed in various tissues with notably high expression in epithelial tissues. The protein primarily localizes at adherens junctions where it interacts with the cell cytoskeleton contributing to cellular stability and organization.
Biological function summary
This protein facilitates cell adhesion and signaling. VEZT forms part of a complex with myosin VIIA which helps in linking cell surface receptors to the actin cytoskeleton. This interaction maintains the structural integrity of tissues and supports cellular processes such as migration and morphogenesis. VEZT's involvement in these processes highlights its function in maintaining proper cellular architecture and communication.
Pathways
VEZT operates within the Wnt signaling pathway a fundamental pathway in controlling cell proliferation and differentiation. It interacts with proteins like beta-catenin within this context. VEZT also plays a role in the cadherin-catenin complex important for cell-cell adhesion. Its interaction with proteins such as E-cadherin in these pathways emphasizes its role in ensuring epithelial cell tissue integrity and function.
VEZT has been linked to cancer progression notably in gastric and breast cancers. Altered expression of VEZT correlates with changes in cell adhesion properties aiding in tumor cell invasion and metastasis. VEZT interacts with proteins such as E-cadherin where disruptions can contribute to the loss of cell adhesion a hallmark of many cancers. Understanding VEZT's role in these pathological conditions can lead to potential therapeutic strategies targeting its molecular interactions.