Abcam, ab45338, Anti-LYRIC/AEG1 antibody

Size: 100µg
Rabbit Polyclonal LYRIC/AEG1 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Mouse, Human, Rat samples. Cited in 20 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LYRIC/AEG1 also known as Astrocyte Elevated Gene-1 (AEG-1) is a protein with a molecular weight of approximately 60 kDa. This protein is expressed in several tissues with notable expression in the brain liver and other organs. LYRIC/AEG1 is encoded by the MTDH gene and plays a mechanical role in regulating processes such as gene expression and cell survival. It localizes to the endoplasmic reticulum the perinuclear region and also the cell nucleus indicating a multifaceted role in cellular dynamics.
Biological function summary
LYRIC/AEG1 functions significantly in oncogenesis and tumor progression. It participates actively in gene regulation and interacts with various proteins as part of complex protein networks influencing cell survival migration and adherence. This protein is known to enhance metastasis and promote angiogenesis in malignant contexts. Researchers often study the modulation of LYRIC/AEG1 to assess its impact on cell proliferation and differentiation in cancer cells.
Pathways
LYRIC/AEG1 is associated with important signaling pathways such as the NF-κB and PI3K/Akt pathways. These pathways are critical for cell survival and proliferation and LYRIC/AEG1 modulates their activity. Through these pathways it interacts with other proteins like IκB kinase complexes and Akt coordinating cellular responses to external stimuli. LYRIC/AEG1’s influence on these pathways highlights its role in cellular adaptation to stress and potential therapeutic interventions.
LYRIC/AEG1’s role becomes apparent in its association with cancers specifically hepatocellular carcinoma and breast cancer. In these cancers LYRIC/AEG1 overexpression correlates with poor prognosis and enhanced tumor progression. Its interaction with proteins such as c-Myc and E-cadherin highlights its involvement in cancer cell metabolism and epithelial-mesenchymal transition (EMT). Understanding LYRIC/AEG1’s function in disease contexts aids in developing targeted treatment strategies for these malignancies.