Abcam, ab45341, Anti-Zfp57 antibody

Size: 100µg
Rabbit Polyclonal ZFP57 antibody. Suitable for WB and reacts with Mouse samples. Cited in 19 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein Zfp57 also known as Zinc finger protein 57 plays a significant mechanical role in the regulation of gene expression. It acts as a transcriptional repressor by binding to DNA methylated sites using its zinc finger domains to recognize specific DNA sequences. The molecular mass of Zfp57 is approximately 58 kDa. Zfp57 is generally expressed in early embryonic stem cells and in the developing mouse embryo indicating a role in early development.
Biological function summary
Zfp57 maintains DNA methylation at imprinted genes essential for genomic imprinting stability. This protein forms a complex with other proteins including TRIM28 (also known as KAP1) which facilitates its function in establishing and maintaining DNA methylation patterns. By interacting with these partners Zfp57 ensures proper transmission of epigenetic marks across generations.
Pathways
The activity of Zfp57 associates with the epigenetic regulation pathway particularly playing a role in the maintenance of DNA methylation imprints. It directly interacts with methyl-DNA binding proteins such as MeCP2 which are important in interpreting methylation signals to adjust chromatin conformation. The proper function of Zfp57 within these pathways is necessary for maintaining normal genomic architecture.
Alterations in Zfp57 function could lead to problems like transient neonatal diabetes mellitus and related imprinting disorders. These conditions arise when there is improper methylation imprint maintenance due to Zfp57 malfunction. Moreover the protein connects to other factors like NLRP7 influencing the risk of imprinting disorders that affect normal growth and development during infancy.