Abcam, ab48197, Anti-SEMA3B antibody

Size: 50µL
Rabbit Polyclonal SEMA3B antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human SEMA3B aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SEMA3B aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q13214,
Specificity:This antibody is specific for SEMA 3B.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: Tris glycine, 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEMA3B also known as Semaphorin-3B is a member of the semaphorin protein family functioning as a guidance cue in neural development. It has an approximate mass of 85 kDa. SEMA3B expresses in various tissues including the nervous system lungs and kidneys. The protein interacts with neuropilin and plexin receptors to mediate its mechanical effects in cell signaling and axonal guidance.
Biological function summary
SEMA3B plays a role in modulating cell migration and apoptosis. As part of the semaphorin family it does not form complexes but signals through receptor interactions. In the nervous system SEMA3B contributes to neural network formation by guiding developing neurons. In addition to its neuronal functions SEMA3B participates in controlling angiogenesis and epithelial cell proliferation acting as a tumor suppressor.
Pathways
SEMA3B is involved in the axon guidance and PI3K/AKT signaling pathways. These pathways are important for cellular movement and survival. SEMA3B interacts with proteins such as neuropilin-1 (NRP1) and plexin-A (PLXNA) which are integral to its signaling pathway. Through these interactions SEMA3B regulates cellular behavior linking it to both neural development and cancer biology.
SEMA3B has strong links to cancer particularly lung and breast cancer where it functions as a tumor suppressor. Altered expression of SEMA3B is observed in these conditions leading to disrupted cellular signaling and uncontrolled cell proliferation. Additionally changes in SEMA3B expression levels associate with neuropilin-1 and other receptors influencing cancer progression and metastasis.