Abcam, ab51026, Anti-TAF6 antibody [585D4a]

Size: 100µg
Mouse Monoclonal TAF6 antibody. Suitable for ICC, IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TAF6.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:585D4a,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TAF6. The exact immunogen used to generate this antibody is proprietary information.P49848

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified using protein G chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum. Filtered through a 0.22 micrometer membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAF6 also known as TAFII70 is a component of the transcription factor IID (TFIID) complex with a mass of about 70 kDa. This protein plays an important role in the initiation of gene transcription by RNA polymerase II. It is expressed in various tissues throughout the body. TAF6 interacts with core promoter elements to facilitate the recruitment of other transcriptional machinery components.
Biological function summary
TAF6 functions as part of the larger TFIID complex which is essential for transcription initiation. The TFIID complex assembles at the core promoter and helps in the recognition and binding of sequence-specific DNA sites. TAF6 contributes to the structural integrity and functional specificity of the complex. These interactions are fundamental for maintaining proper gene expression patterns within cells.
Pathways
TAF6 is integral to transcription regulation pathways such as those initiating from the TATA box within promoters. It works closely with other TFIID components like TATA-binding protein (TBP) and TAF1. Through these interactions TAF6 ensures the correct positioning of RNA polymerase II for efficient transcription initiation. Another pathway involving TAF6 is the MAPK signaling pathway where TAF6 can influence transcriptional responses to external signals.
Alterations in TAF6 expression or function have been implicated in certain cancers such as colorectal cancer. TAF6 can also interact with p53 a well-known tumor suppressor protein linking it to cancer progression pathways. Mutations or dysregulation of TAF6 may affect p53-mediated stress responses contributing to tumor development and progression.