Abcam, ab51235, Anti-HOXA7 antibody [743C1a]

Size: 100µg
Mouse Monoclonal HOXA7 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXA7.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:743C1a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HOXA7. The exact immunogen used to generate this antibody is proprietary information.P31268

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab51235 was purified from culture supernatant of the hybridoma, cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXA7 also known as Homeobox A7 is a transcription factor in the HOX family involved in regulating gene expression. This protein plays a role in developmental processes by binding to specific DNA sequences. It has a molecular weight of around 25 kDa. The expression of HOXA7 occurs in various tissues but it is especially abundant in embryonic tissues indicating its role in early developmental stages. The protein’s activity is important for proper cell differentiation and positioning within developing organisms.
Biological function summary
HOXA7 participates in controlling the developmental blueprint of an organism. It acts as a transcriptional regulator within the family of homeobox genes which functions in concert to ensure organs and tissues develop in the correct order and positions. HOXA7 forms a part of the larger homeobox complex interacting with other HOX proteins to coordinate the precise expression of target genes. Disruptions in its activity can lead to misregulation of these essential developmental processes.
Pathways
The mechanistic activities of HOXA7 relate closely to the Wnt signaling pathway and the cell differentiation pathway. It cooperates with other HOX proteins such as HOXA9 and HOXB4 to modulate gene expression during development. The Wnt signaling pathway in particular plays an important role in cell proliferation and axis patterning. Its interaction with Wnt-related proteins helps achieve spatial and temporal regulation of developmental genes contributing to the finely tuned process of morphogenesis.
Aberrations in HOXA7 expression or function link to certain cancers and developmental disorders. In leukemia researchers observe abnormal expressions of HOXA7 suggesting it may contribute to the dysregulation of cell proliferation associated with this disease. Additionally the protein relates to skeletal malformations where its dysfunction results in improper bone development. In these contexts HOXA7 may interact with proteins such as MEIS1 which can modify its activity and impact cellular outcomes associated with these conditions.