Abcam, ab51252, Anti-alpha + beta Synuclein antibody [EP1646Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Alpha-synuclein antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Mouse, Human, Rat samples. Cited in 28 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1646Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha-synuclein and beta-synuclein are proteins implicated in the dynamics of neuronal function. Alpha-synuclein also known as SNCA is a synaptic protein weighing approximately 14 kDa expressed highly in the central nervous system. Unlike alpha-synuclein beta-synuclein shares a similar structure but differs in function and molecular weight. Both proteins belong to the synuclein family which also includes gamma-synuclein and are found primarily in pre-synaptic terminals contributing to synaptic vesicle physiology.
Biological function summary
Alpha- and beta-synuclein play roles in synaptic function and plasticity where they influence neurotransmitter release and vesicle recycling. These proteins do not generally form a stable complex with each other but their presence together suggests a regulatory interplay. Alpha-synuclein may promote vesicle formation and trafficking while beta-synuclein appears to counteract alpha's effects potentially protecting neurons from alpha-synuclein aggregation.
Pathways
Alpha- and beta-synuclein are key components in the synaptic vesicle cycle especially associated with the SNARE complex and neurotransmitter balance. Alpha-synuclein interacts with proteins like VAMP2 and STX1A in vesicle merging while beta-synuclein's regulatory role has implications in maintaining these interactions. In lipid metabolism alpha-synuclein influences fatty acid binding protein pathways impacting neuronal lipid transport and homeostasis.
Alpha- and beta-synuclein hold significant relevance particularly in neurodegenerative disorders like Parkinson's disease and dementia with Lewy bodies which show marked alpha-synuclein aggregates known as Lewy bodies. Alpha-synuclein's accumulation in neurons correlates with disease progression. Beta-synuclein on the other hand appears to have a protective role potentially mitigating the toxicity of alpha's aggregates. The relation between these synucleins underlines their importance in therapeutic research for these disorders.