Abcam, ab51506, Anti-SCML2 antibody [SCMAD14A]

Size: 100µg
Mouse Monoclonal SCML2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Sex comb on midleg-like protein 2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SCMAD14A,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Sex comb on midleg-like protein 2. The exact immunogen used to generate this antibody is proprietary information.Q9UQR0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab51506 purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, 0.812% Sodium chloride, 0.1136% Disodium hydrogenorthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCML2 also known as Sex Comb on Midleg-Like Protein 2 is a Polycomb group protein involved in transcriptional regulation. It is part of a larger family of proteins characterized by a SPM domain and SCML2 itself has a molecular mass of approximately 100 kDa. SCML2 is expressed in various tissues with significant levels found in testis and brain tissue. Its presence contributes to the maintenance of transcriptional repression of specific genes maintaining proper cellular function.
Biological function summary
SCML2 interacts with other proteins within the Polycomb repressive complex helping regulate gene expression during development and differentiation. SCML2 binds to chromatin and represses genes involved in cell cycle regulation and developmental processes. By modulating these genes it plays an important role in maintaining the silenced state of target genes which is necessary for proper cell function and development.
Pathways
SCML2 participates in the Polycomb group pathway which is important for maintaining gene repression across generations of cells. This protein interacts with other Polycomb proteins like PRC1 and PRC2 which are essential for the propagation of repressive histone marks. These interactions lead to the compacting of chromatin influencing genes concerned with growth and proliferation.
SCML2 dysfunction is linked to certain cancers including testicular cancer due to its role in regulation of gene expression. Disrupted SCML2 may affect the pathways related to BRCA1 a protein that also contributes to genomic stability and suppresses tumors. Studies have shown that abnormalities in SCML2 can lead to imbalance in gene repression making cells more prone to uncontrolled growth and proliferation.