Abcam, ab51550, Anti-Tryptophan rich protein antibody

Size: 100µg
Chicken Polyclonal Tryptophan rich protein antibody. Suitable for WB and reacts with Recombinant full length protein - Human samples. Cited in 2 publications.
Key facts
Host species:Chicken,
Clonality:Polyclonal,
Isotype:IgY,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GET1.O00258

Properties and Storage Information:
Form-Liquid, Purity-IgY fraction, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tryptophan-rich proteins mechanically function as structural components and cellular signaling molecules. Known also by alternate names depending on their specific forms or isoforms these proteins exhibit varying masses often around 15 kDa though the mass can differ among species. One notable example is found in chickens expressed primarily within specialized cells and tissues indicating roles in cell signaling and tissue-specific processes. Various isoforms can be identified in different organisms with expression patterns linked to their specific physiological functions.
Biological function summary
Tryptophan-rich proteins contribute to processes like immune response modulation and cell adhesion impacting cellular communication and structural integrity. These proteins sometimes form part of larger protein complexes enhancing their stability and function in the cellular environment. Tryptophan-rich proteins interact with a spectrum of cellular receptors and other proteins thereby influencing cascade reactions essential for cell maintenance and signal transduction.
Pathways
Research identifies tryptophan-rich proteins as integral components of immune signaling and adhesion-related pathways. They often engage with proteins like integrins important in linking extracellular matrices to the cytoskeleton. Such engagement facilitates cellular communication and migration ensuring proper immune response and tissue maintenance. Interactions with these pathways highlight the protein's importance in maintaining physiological balance and cellular integrity.
Tryptophan-rich proteins hold links to conditions such as autoimmune diseases and chronic inflammation. Aberrations in these proteins can lead to dysregulated immune responses contributing to the pathogenesis of autoimmune conditions. Connections to proteins like cytokines which regulate inflammation elucidate their role in chronic inflammatory states. Understanding their function and interaction with disease-related pathways holds potential for developing targeted therapies.