Abcam, ab52495, Anti-Radixin/RDX antibody [EP1862Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Radixin/RDX antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 31 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1862Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:ICC/IF, IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Radixin also known as RDX is a member of the ezrin-radixin-moesin (ERM) family of proteins. It weighs approximately 68 kDa and is expressed in a variety of tissues with high levels found in the brain liver and intestines. Radixin functions mechanically by binding to actin filaments and linking them to the plasma membrane. This process is essential for maintaining cell shape and facilitating signal transduction.
Biological function summary
Radixin plays a role in modulating cell surface structure which influences microvilli formation and stability. Radixin serves as a linkage between the actin cytoskeleton and the plasma membrane which helps in forming actin-rich surface structures. It does not function alone; it often acts as part of larger complexes that control cytoskeleton-related activities. Its role in maintaining cellular architecture makes it integral to processes like cell adhesion migration and polarization.
Pathways
Radixin is an important component in signaling pathways that regulate the cytoskeleton and cell membrane interactions. Key pathways include the Rho family of GTPases and the PI3K/Akt pathway. Radixin interacts with these pathways by connecting with proteins such as RhoA which regulates actin dynamics and Akt which influences cell survival and growth. These interactions are important for cellular responses to environmental and internal signals.
Improper function of radixin relates to certain pathological conditions including hepatocellular carcinoma and cholestasis. In hepatocellular carcinoma radixin impacts cell proliferation and migration making it a potential target for cancer therapy. In cholestasis radixin dysfunction has connections with altered bile canalicular structures often interacting with proteins like CFTR. These associations highlight its significance as a potential target for therapeutic strategies aiming to correct cellular structures in these disorders.