Abcam, ab52632, Anti-CD11c antibody [EP1347Y] - C-terminal

Size: 20µL / 100µL / 1mL
Anti-CD11c antibody [EP1347Y] - C-terminal (ab52632) is a rabbit monoclonal antibody detecting CD11c in Western Blot, IP, IHC-P . Suitable for Human . - Biophysical QC for unrivalled batch-batch consistency - Over 110 publications - Trusted since 2007
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1347Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-CD11c antibody [EP1347Y] - C-terminal (ab52632) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P, IP, WB in human samples.
Anti-CD11c antibody [EP1347Y] - C-terminal (ab52632) has been cited over 119 times in peer reviewed journals and is trusted by the scientific community.
Abcams high quality manufacturing and validation processes ensure Anti-CD11c antibody [EP1347Y] - C-terminal (ab52632) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-CD11c antibody [EP1347Y] - C-terminal (ab52632) has 16 independent reviews from customers.
Anti-CD11c antibody [EP1347Y] - C-terminal (ab52632) specifically detects CD11c (UniProt ID: P20702; Molecular weight: 126kDa) and is sold in a convenient trial size to enable initial testing (20 uL) and larger sizes for subsequent scaling up experiments (100 uL and 1 mL).
Conjugation-ready, carrier free format available for antibody clone EP1347Y -
ab216655
Antibody clone EP1347Y is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 594, Alexa Fluor® 555, Biotin (
ab195534
ab275338
ab275738
ab277235
ab279329
, ab32232).
CD11c is a marker for dendritic cells, playing a pivotal role in antigen presentation and immune regulation, particularly in autoimmune diseases. CD11c is a potential therapeutic target in anti-tumor immune responses, multiple sclerosis and rheumatoid arthritis.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.
Biological function summary
CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.
Pathways
CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.
CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.