Abcam, ab53951, Anti-Angiotensin I antibody

Size: 150µg
Rabbit Polyclonal Angiotensinogen antibody. Suitable for IP, ELISA, RIA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AGT aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:RIA, IP, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AGT aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P01019

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Angiotensin I also known as Ang I acts as a precursor in the renin-angiotensin system. Its molecular mass is approximately 1296.5 Da. Angiotensin I originates from the cleavage of angiotensinogen by the enzyme renin primarily in the liver. This decapeptide circulates in the bloodstream and serves as a substrate for further enzymatic reactions. Although it itself does not have known biological activity its conversion to angiotensin II enhances its significance.
Biological function summary
The conversion of angiotensin I into angiotensin II is an important step. This reaction occurs in the lungs facilitated by the angiotensin-converting enzyme (ACE). Angiotensin II has much greater activity and plays an important role in increasing blood pressure and regulating blood volume. Angiotensin I serves as an important precursor member but not an active component of this system and enemies an intricate balance with other components like prorenin and renin.
Pathways
Angiotensin I's role is central in the renin-angiotensin-aldosterone system (RAAS). This pathway involves the conversion sequence involving renin Ang I ACE and angiotensin II leading further to the release of aldosterone. Angiotensin I plays a continuous part alongside other proteins such as ACE and angiotensinogen that integrate into the larger RAAS highlighting its intermediary function within this cardiovascular regulatory system.
Angiotensin I indirectly connects to hypertension and heart failure through its conversion to angiotensin II. Elevated levels of angiotensin II the main active agent can contribute to increased blood pressure and cardiovascular strain. The connection between angiotensin I and ACE accentuates its role in this pathological process even though Ang I itself is not directly pathogenic. Understanding this relationship provides insights into hypertension treatment strategies focusing on targeting ACE or using angiotensin I ELISA kits to monitor systemic levels.