Abcam, ab55044, Anti-GPCR GPRC5D antibody [6D9] - BSA and Azide free

Size: 100µg
Anti-GPCR GPRC5D antibody [6D9] - BSA and Azide free (ab55044) is a mouse monoclonal antibody provided in a PBS only buffer for easy conjugation detecting GPCR GPRC5D in Western Blot . - BSA, sodium azide, and glycerol-free for easy conjugation - Trusted since 2007
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:6D9,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:Yes,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GPRC5D aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NZD1

Product details:
What is this antibody validated in?
Anti-GPCR GPRC5D antibody [6D9] - BSA and Azide free (ab55044) is a mouse monoclonal antibody and is validated for use in Western Blot (WB).
What is the molecular weight of GPCR GPRC5D?
Anti-GPCR GPRC5D [6D9] - BSA and Azide free (ab55044) specifically detects a band for GPCR GPRC5D (UniProt: Q9NZD1) at a molecular weight of 39kDa.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GPCR GPRC5D also known as the GPRC5D protein or by the code 6D9 in certain research contexts is a member of the G-protein-coupled receptors (GPCRs) superfamily. This family acts as a significant mediator of cellular responses to external signals. The GPRC5D has a mass of approximately 56 kDa. It is mainly expressed in the human bone marrow and the keratinocytes of the skin with notable absence in other tissues. It also appears in certain immune cells indicating its potential involvement in immune system responses.
Biological function summary
The role of GPCR GPRC5D centers on cell signaling mechanisms within the immune system. GPCR GPRC5D engages in intracellular signaling cascades that modulate immune functions although it is not known to be part of a larger receptor complex. Its function may involve interactions with molecules that transmit environmental signals into cellular responses enhancing its importance in immune regulation and possibly other cellular functions.
Pathways
GPCR GPRC5D participates in signaling pathways like the immune regulation pathway and the skin development pathway. It relates to proteins such as arrestins which link GPCRs to downstream signaling pathways. This connection hints at a regulatory role in cellular response where GPCR GPRC5D acts as a conduit for signal transduction balancing cellular responses to external stimuli and maintaining cellular homeostasis.
GPCR GPRC5D has associations with multiple myeloma and psoriasis. Its expression in bone marrow links it to multiple myeloma where its level might impact cancer progression. Proteins such as interleukin-17 and others relevant to psoriasis are connected to GPCR GPRC5D through skin-related pathways suggesting its role in inflammatory responses and potential as a therapeutic target for skin disorders. This illustrates GPRC5D's relevance in specific pathological conditions offering avenues for research into targeted treatments.