Abcam, ab55255, Anti-HOXD11 antibody [5G4]

Size: 100µg
Mouse Monoclonal HOXD11 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXD11 aa 1-100.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:5G4,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HOXD11 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P31277

Product details:
This product was changed from ascites to tissue culture supernatant on 27 June 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-Purified from TCS., Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HOXD11 gene belongs to the homeobox (HOX) gene family which encodes transcription factors that regulate developmental processes. HOXD11 is also known as Homeobox D11 and it has an estimated molecular mass of approximately 35 kDa. This transcription factor primarily localizes in the nucleus where it influences gene expression. Expression of HOXD11 occurs significantly in embryonic limb bud development and has been observed in various tissues such as the kidney and neural tissues.
Biological function summary
The actions of HOXD11 involve regulation of embryonic morphogenesis and limb patterning. It functions as part of the larger HOXD gene cluster which includes several homeobox genes that coordinate spatial and temporal gene expression. The coordinated expression in these clusters aids in accurately forming skeletal elements particularly affecting phalanges and the radius. HOXD11 plays a significant role in defining the specific identity of limb segments by influencing the transcription of downstream target genes.
Pathways
The HOXD11 gene plays a notable role in the development of anatomical structures specifically through the Wnt signaling and Hedgehog signaling pathways. These pathways are important in regulating tissue patterning during embryonic development. In these processes HOXD11 interacts with other HOX proteins to provide positional identity and growth patterning. The interaction of HOXD11 with WNT and SHH proteins highlights its importance in the proper formation of limbs and other skeletal structures.
Misregulation or mutations in HOXD11 link to congenital limb malformations such as synpolydactyly and carpal-tarsal osteochondromatosis which affect hand and foot development. Its involvement in these diseases highlights the necessity for precise gene regulation during limb formation. Additionally interactions with other HOX genes in disorders showcase a complex interplay between HOX family members that can contribute to developmental abnormalities.