Abcam, ab57494, Anti-TAF7 antibody [2C5]

Size: 100µg
Mouse Monoclonal TAF7 antibody. Suitable for Flow Cyt, WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TAF7 aa 100-250.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2C5,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TAF7 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q15545

Product details:
This product was changed from ascites to tissue culture supernatant on 12
June 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAF7 also known as transcription initiation factor TFIID subunit 7 plays a critical role in transcription initiation. This protein is approximately 61 kDa in mass. TAF7 is a component of the TFIID complex which is important in assembling the pre-initiation complex necessary for RNA polymerase II to initiate transcription. TAF7 expression is widespread with high expression levels observed in various tissues including the liver and muscle.
Biological function summary
TAF7 functions as an integral part of the TFIID complex. The TFIID complex consisting of TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs) is essential for the accurate transcription of genes by RNA polymerase II. TAF7 influences the assembly and stability of the TFIID complex thereby affecting the transcriptional regulation. It not only interacts directly with other TAFs such as TAF1 and TAF5 but also serves as a regulatory checkpoint in the transition from transcription initiation to elongation.
Pathways
The TAF7 protein acts significantly within the transcription initiation pathway. This pathway is vital for the expression of eukaryotic genes. TAF7 through its interaction with TAF1 and other TAFs contributes to the formation of the pre-initiation complex. By doing so it ensures the proper positioning of RNA polymerase II and the commencement of mRNA synthesis. It also plays a role in pathways controlling cell cycle regulation and development by influencing gene expression critical for growth and cellular responses.
Altered expression or mutations in TAF7 are linked to specific cancers like hepatocellular carcinoma demonstrating its importance in cell proliferation and survival. Furthermore due to its role in gene regulation TAF7 abnormalities can relate to neurodevelopmental disorders. Proteins such as TAF1 have shown connections to disorders linked to transcriptional dysregulation highlighting the interconnected nature of transcription components like TAF7 in various pathological conditions.