Abcam, ab58652, Anti-HIVEP1 antibody [2417C2 a]

Size: 100µg
Mouse Monoclonal HIVEP1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HIVEP1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2417C2 a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HIVEP1. The exact immunogen used to generate this antibody is proprietary information.P15822

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab58652 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.1136% Disodium hydrogenorthophosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HIVEP1 also known as ZAS1 is a transcription factor with a molecular mass of approximately 310 kDa. It plays a role in regulating gene expression by binding to specific DNA sequences. HIVEP1 exhibits expression in various tissues with higher levels found in immune-related tissues including the spleen and lymph nodes. The interaction with DNA allows HIVEP1 to act as a transcriptional integrator contributing to the control of gene networks involved in immune responses.
Biological function summary
HIVEP1 influences the transcriptional activation of genes important for immune system functioning. It forms part of a multi-protein complex that modulates the expression of genes involved in B and T cell development. The activity of HIVEP1 in the immune response emphasizes its essential role in maintaining immune system integrity and proper lymphocyte function. Through its conserved zinc finger motifs HIVEP1 binds to NF-kB response elements affecting the NF-kB signaling pathway.
Pathways
HIVEP1 interacts with the NF-kB signaling pathway and influences processes of immune regulation. This signaling pathway supports inflammatory responses cell survival and proliferation. HIVEP1's regulation of NF-kB is similar to that of other proteins like IKK and p65. Together they coordinate responses to immune challenges by altering transcriptional programs needed during inflammation and adaptive immunity.
HIVEP1 has connections to autoimmune diseases and certain types of cancers. Dysregulation of HIVEP1 expression significantly affects immune cell function potentially leading to conditions like rheumatoid arthritis. In cancer alterations in HIVEP1 function can contribute to improper cell proliferation and survival highlighting interactions with proteins such as c-Rel. Understanding HIVEP1's role shows the importance of maintaining its normal functioning within the immune system and cell growth pathways.