Abcam, ab59770, Anti-NUFIP1 antibody [2662C1a]

Size: 100µg
Mouse Monoclonal NUFIP1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NUFIP1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2662C1a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NUFIP1. The exact immunogen used to generate this antibody is proprietary information.Q9UHK0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Filtered through a 0.22 µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NUFIP1 or Nuclear Fragile X Mental Retardation Interacting Protein 1 functions as an important component in ribosome biogenesis. It has a molecular mass of approximately 90 kDa. This protein interacts with ribosomal RNA and facilitates the stabilization of the 90S pre-ribosomal particle. NUFIP1 exists in multiple cellular compartments including the nucleolus which indicates its role in ribosome assembly and processing within the nuclear environment.
Biological function summary
NUFIP1 contributes to the maturation of ribosomal RNA as part of the ribonucleoprotein complex specifically the box C/D snoRNP complex. Its involvement in the assembly of ribosomal components is essential for the proper synthesis of ribosomes. NUFIP1's role in snoRNPs suggests it participates in chemical modifications on rRNA most notably methylation a critical modification in the ribosome's function.
Pathways
NUFIP1 actively participates in the ribosome biogenesis in the nucleolus and cytosolic ribosome pathways. It interacts closely with partner proteins like SURF6 and NOP58 which are critical components in these pathways. These interactions ensure the proper production and function of ribosomes ensuring effective cellular protein synthesis.
Researchers have linked abnormalities in NUFIP1 to disorders such as Fragile X syndrome and cancer. In Fragile X syndrome its interaction with the fragile X mental retardation protein (FMRP) highlights its importance in neuronal development. In cancer dysregulation in ribosome synthesis where NUFIP1 is involved can lead to uncontrolled cell growth illustrating its potential role in tumorigenesis.