Abcam, ab59971, Anti-SPNS1 antibody

Size: 100µL
Rabbit Polyclonal SPNS1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SPNS1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SPNS1. The exact immunogen used to generate this antibody is proprietary information.Q9H2V7,
Specificity:This antibody reacts specifically with human 56 kDa SPNS1 protein.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SPNS1 also known as Spinster homolog 1 is a transporter protein with a molecular weight of approximately 39 kDa. This protein is mainly found in tissues such as placenta brain lung and kidney. Mechanically SPNS1 functions as a transporter that facilitates the movement of sphingosine-1-phosphate (S1P) across the cellular membranes. This transport activity plays an essential role in regulating S1P levels within and outside cells impacting various cellular processes.
Biological function summary
SPNS1 serves as a pivotal regulator in lipid signaling and cell migration. It is part of a system that balances the synthesis and degradation of S1P influencing numerous cellular functions including immune cell trafficking and vascular development. SPNS1’s activity is integral to maintaining the cellular gradient of S1P necessary for directing cellular responses in physiological contexts like immune response and cellular development. Its function links to several cellular outcomes making it a significant player in cellular communication.
Pathways
SPNS1 significantly contributes to the sphingolipid signaling pathway and the vascular endothelial growth factor (VEGF) pathway. Within the sphingolipid signaling pathway SPNS1 works closely with sphingosine kinases which phosphorylate sphingosine to S1P and S1P receptors that mediate downstream signaling. In the VEGF pathway SPNS1 indirectly influences angiogenesis through lipid signaling mediators. These pathways highlight the interactions of SPNS1 with other pivotal proteins like sphingosine kinases and S1P receptors.
SPNS1 holds relevance to conditions like cancer and autoimmune disorders. Its role in sphingolipid signaling associates it with cancer progression where altered S1P levels can affect tumor growth and metastasis. In autoimmune disorders dysregulated S1P signaling potentially involving SPNS1 can influence immune cell migration and function aggravating disease symptoms. Proteins like sphingosine kinases and S1P receptors are also involved in these diseases linking further to SPNS1's impact on pathological states.