Abcam, ab60063, Anti-UTP3 antibody [2950C2a]

Size: 100µg
Mouse Monoclonal UTP3 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human UTP3.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2950C2a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human UTP3. The exact immunogen used to generate this antibody is proprietary information.Q9NQZ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab60063 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.1136% Disodium hydrogenorthophosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UTP3 also known as Utp3p is a component of the small subunit processome involved in ribosome biogenesis. This protein has a mass of approximately 65 kDa and mainly localizes in the nucleolus of eukaryotic cells. UTP3 plays an important role in the early steps of 18S rRNA processing as part of the preribosomal particle assembly. This early involvement is essential for the production of the small ribosomal subunit which impacts protein synthesis.
Biological function summary
UTP3 engages in ribosome assembly interacting with other proteins within the small subunit (SSU) processome complex. This complex processes pre-rRNA into mature rRNA critical for ribosome function. UTP3's role ensures the accuracy and efficiency of rRNA folding and processing which is essential for the assembly of functional ribosomal units in eukaryotic cells.
Pathways
UTP3 is highly involved in the ribosome biogenesis pathway. This pathway is critical for cell growth and proliferation as it directly affects translation and protein synthesis. UTP3 associates with other SSU processome proteins like UTP4 and UTP15 facilitating pre-rRNA processing and ribosome assembly. These interactions highlight UTP3's importance in maintaining the integrity of the protein synthesis machinery.
Abnormalities in UTP3 function can relate to ribosomopathies and cancer. Disruptions in ribosome biogenesis involving proteins like UTP3 can lead to improper cell growth and proliferation often noted in cancers. Additionally any aberration in its interaction with other nucleolar proteins like UTP4 may further impact disease manifestation reflecting UTP3's significance in maintaining cellular homeostasis.