Abcam, ab60065, Anti-NARG1 antibody [434C2a]

Size: 100µg
Mouse Monoclonal NARG1 antibody. Suitable for WB and reacts with Recombinant fragment samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NAA15.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:434C2a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NAA15. The exact immunogen used to generate this antibody is proprietary information.Q9BXJ9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified using protein G column chromatography, from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NARG1 also known as NARGG or NMDA receptor-regulated gene protein 1 is a protein with a molecular mass of approximately 152 kDa. NARG1 directly participates in protein acetylation by transferring acetyl groups to lysine residues an important post-translational modification affecting protein function and interactions. This protein is expressed across various tissues with notable presence in the brain heart and testis indicating its diverse functional roles within different physiological contexts.
Biological function summary
The acetyltransferase activity of NARG1 significantly impacts gene regulation and cellular homeostasis. It forms part of the NatA complex where it functions together with other components such as NAA10 and NAA15. This complex plays a role in co-translational N-terminal acetylation influencing protein stability and function. NARG1's activity particulary affects processes like cell cycle progression apoptosis and cellular differentiation reflecting its importance in maintaining cellular balance.
Pathways
NARG1 activity links prominently to the signaling pathway of mRNA translation which is essential for protein synthesis and cellular growth. Additionally it participates in the regulation of apoptosis pathways modulating cell survival in response to various stress signals. Proteins like p53 and BCL-2 show interactions with these pathways revealing how NARG1 may influence key cellular outcomes and decision points regarding survival and death.
Studies have connected NARG1 to neural development and certain neurodegenerative conditions. Aberrations in NARG1 expression or function may contribute to disorders like Alzheimer’s Disease potentially affecting neuronal survival and cognitive function. The protein's role is also noteworthy in the context of cardiac hypertrophy where its regulatory capacity on cellular growth pathways can impact heart muscle function. Related proteins affected by these conditions may include components like tau in neurodegeneration and myosin heavy chain in cardiac pathophysiology.