Abcam, ab61430, Anti-Frizzled 9 antibody

Size: 50µg
Rabbit Polyclonal Frizzled 9 antibody. Suitable for IHC-FoFr, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FZD9 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-FoFr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FZD9 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O00144

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.7Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Frizzled 9 also known as FZD9 or the frizzled class receptor 9 acts as a receptor for Wnt proteins. This protein is a member of the Frizzled family involved in the Wnt signaling pathway. Frizzled 9 has an approximate mass of 67 kDa. Researchers have found that it expresses in various tissues particularly in the brain lungs and bone. Its expression pattern indicates a role in both development and disease processes.
Biological function summary
Frizzled class receptor 9 functions in cellular communication and development. It does not operate alone but often forms complexes with co-receptors like LDL receptor-related protein 5/6 (LRP5/6). Through these complexes it transmits signals important for various cellular functions such as proliferation differentiation and migration. Frizzled 9’s signaling affects cellular processes contributing significantly to maintaining normal cellular homeostasis.
Pathways
Frizzled receptor 9 participates in the Wnt/β-catenin signaling and the planar cell polarity (PCP) pathway. In the Wnt/β-catenin pathway frizzled 9 interacts with proteins such as β-catenin and Dishevelled (Dvl) leading to gene expression changes. In the PCP pathway frizzled 9 contributes to the regulation of cellular orientation within tissues. Through these pathways frizzled 9 plays a role in cell fate determination and tissue patterning making it an important component in organismal development and disease.
Alterations in frizzled 9 function link to osteoporosis and cancer. Its expression levels and signaling efficiency can impact bone density connecting it to LRP5/6 in osteoporosis. Abnormal frizzled 9 signaling may also influence cancer development as disruptions in the Wnt pathway are known to affect cell proliferation and tumor growth. Understanding frizzled 9’s interplay with these proteins provides insight into its role in disease mechanisms and potential therapeutic implications.