Abcam, ab62667, Anti-Agmatine antibody

Size: 100µL
Chicken Polyclonal Agmatine antibody. Suitable for ICC and reacts with Chemical samples. Cited in 2 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Agmatine.
Key facts
Host species:Chicken,
Clonality:Polyclonal,
Isotype:IgY,
Carrier free:No,
Applications:ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Fixed tissue cross-reactivity tested with known targets at recommended dilution. No measurable glutaraldehyde-fixed tissue cross-reactivity (<1:1000) against L-alanine, gamma-aminobutyrate, L-citrulline, L-cysteine, D/L-glutamate, D/L-arginine, D/L-glutamine, glutathione, glycine, L-lysine, L-ornithine, L-serine, taurine, L-threonine, L-tryptophan, L-tyrosine.

Properties and Storage Information:
Form-Liquid, Purity-IgY fraction, Purification notes-IgYs were separated from other yolk proteins by serial PEG6000 extractions using a modification of the method of Polsonet al Immunological Investigations. 1985, 14, 323-327., Storage buffer-Preservative: 0.05% Thimerosal (merthiolate)Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Agmatine is a biological molecule derived from the amino acid arginine often referred to as decarboxylated arginine. It has a molecular mass of approximately 130.19 g/mol. Agmatine is found widely in various tissues with a high expression in the brain and other vital organs. Notably it is distributed in neurons where it modulates multiple physiological functions. Agmatine also appears endogenously in the human body and it can be detected in trace amounts.
Biological function summary
This compound plays important roles beyond being a metabolic product. It acts as a neuromodulator and neurotransmitter in the central nervous system. Agmatine interacts with multiple biochemical targets including ionotropic receptors and imidazoline receptors. It is also studied for being involved in signal transduction pathways. As part of its complex functions agmatine influences nitric oxide synthesis by modulating nitric oxide synthase activity.
Pathways
Several components and mechanisms connect agmatine to essential cellular processes. It plays roles in the polyamine pathway and influences the regulation of nitric oxide. These pathways contribute to cellular proliferation and angiogenesis. Agmatine interacts with related proteins like arginase and ornithine decarboxylase highlighting its regulative potential within the polyamine framework.
Different pathways show a strong connection between agmatine and certain health conditions. Studies indicate that agmatine may have implications in neurodegenerative diseases such as Alzheimer's disease due to its neuromodulatory activity. Additionally its impact on nitric oxide synthase links agmatine to cardiovascular diseases. These connections involve proteins such as amyloid precursor protein in Alzheimer's and enzymes in the nitric oxide pathway contributing to cardiovascular health.