Abcam, ab63169, Recombinant human TAOK1 protein

Size: 10µg
Recombinant human TAOK1 protein is a Human Fragment protein, in the 1 to 314 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>90% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Specific activity: 1670 nmol/min/mg.,
Accession:Q7L7X3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0038% EGTA, 0.00292% EDTA, 0.00174% PMSF

Product details:
ab64311
(Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAOK1 also known as TAO kinase 1 or PSK2 is a serine/threonine-protein kinase with a mass of about 125 kDa. It is expressed in various tissues including the brain heart and liver. This protein primarily influences cellular processes through phosphorylation which affects the activity of downstream effectors and can alter cellular responses to different stimuli. The full-length protein facilitates signal transduction pathways within cells leveraging its kinase activity to influence cellular structures and communication.
Biological function summary
TAOK1 participates in important cellular mechanisms such as cytoskeletal organization and cell cycle regulation. It functions as an integral component of complexes that manage these processes working through phosphorylation to modulate activities of other proteins. TAOK1 has a significant role in mitotic events ensuring proper chromosome segregation and maintaining genomic stability. Its kinase activity is important for signaling pathways that govern cellular responses to environmental challenges and stress.
Pathways
The participation of TAOK1 can especially be observed in the MAPK and stress-activated protein kinase (SAPK) pathways. These pathways are essential for transmitting extracellular signals into intracellular responses regulating processes like apoptosis and cytoskeletal rearrangement. TAOK1 interacts with related proteins such as MAP3K7 (also known as TAK1) to propagate signals that adapt cellular states under stress conditions. This interaction suggests a cooperative role in managing cellular response and survival during varying conditions.
TAOK1 exhibits associations with neurological disorders and cancer. Abnormal expression or mutation of TAOK1 affects its kinase activity contributing to conditions like neurodevelopmental disorders and glioblastoma. It interacts with key proteins such as p53 a well-known tumor suppressor gene underlying its maybe involvement in cancer pathways. These associations highlight the importance of TAOK1 as a potential biomarker or therapeutic target in disease management and treatment strategies.