Abcam, ab64636, Anti-Frizzled 7 antibody

Size: 100µg
Rabbit Polyclonal Frizzled 7 antibody. Suitable for IHC-P, ICC/IF, WB and reacts with Human, Rat, Mouse samples. Cited in 32 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Replenishment batches of ab64636 are tested in WB. Previous batches were additionally validated in ICC/IF and IHC-P. These applications are still expected to work and are covered by our Abpromise guarantee.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Frizzled 7 also known as Frizzled receptor or Frizzled protein is a transmembrane receptor weighing approximately 75 kDa. This member of the Frizzled family acts as a receptor for Wnt proteins and plays a role in the transmission of extracellular signals to the cytoplasm. Frizzled 7 is expressed in various tissues but shows prevalent expression in organs like the intestine and kidney. The receptor's structure includes a distinctive cysteine-rich domain essential for ligand binding which sets it apart in the family of Frizzled receptors.
Biological function summary
Frizzled 7 functions in cellular processes such as regulating cell proliferation migration and differentiation. It interacts closely with Dishevelled proteins to activate downstream signaling cascades. As part of a signaling complex Frizzled 7 influences the stabilization and localization of key signaling molecules within the Wnt/β-catenin pathway. This protein's role is vital in maintaining cellular responses necessary for tissue homeostasis and development.
Pathways
Wnt/β-catenin and planar cell polarity pathways are the primary pathways involving Frizzled 7. The Wnt/β-catenin pathway sees this receptor interacting with proteins like LRP5/6 and β-catenin to regulate gene expression. Through these pathways Frizzled 7 helps balance cellular activities that ensure proper tissue growth and repair. These pathways highlight its coordination with other Frizzled receptors to bring about specific cellular responses.
Frizzled 7 has been linked to colorectal cancer and kidney diseases. Alterations in the Wnt signaling pathways where Frizzled 7 takes part can lead to uncontrolled cell proliferation contributing to tumor progression. Frizzled 7 has shown significant interactions with proteins such as APC in the development of colorectal cancer. Additionally its atypical expression levels may correlate with kidney disease progression linking it to aberrations in cellular signaling that disrupt normal kidney function. These connections highlight the receptor's potential as a therapeutic target in these disorders.