Abcam, ab64693, Anti-Mannose Receptor antibody

Size: 100µg
Anti-Mannose Receptor antibody (ab64693) is a rabbit polyclonal antibody detecting Mannose Receptor in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Over 750 publications - Trusted since 2009
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Product details:
Anti-Mannose Receptor antibody (ab64693) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P and WB.
Anti-Mannose Receptor antibody (ab64693) was first used in a scientific publication in 2010 and has been cited over 750 times in peer reviewed journals. It's performance in Western blot and IHC in human, mouse and rat samples is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-Mannose Receptor antibody (ab64693) has high sensitivity and specificity.
Anti-Mannose Receptor antibody (ab64693) has 38 independent reviews from customers.
Anti-Mannose Receptor antibody (ab64693) specifically detects Mannose Receptor (UniProt ID: P22897; Molecular weight: 165kDa) and is sold in 100 ug selling sizes.
Mannose receptor (CD206) is associated with conditions like rheumatoid arthritis and atherosclerosis, where it helps regulate inflammation

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Mannose Receptor also known as CD206 or MRC1 is a transmembrane protein that plays a role in the endocytic pathway. With a molecular weight of approximately 175 kDa it is expressed primarily in macrophages and dendritic cells. This receptor binds to mannose fucose and N-acetylglucosamine residues present on glycoproteins and microorganisms. It functions as an image receptor that facilitates uptake and removal of external particles.
Biological function summary
Mannose receptor performs essential functions in immune response modulation. It is not part of any known protein complex but can interact with other proteins on the cell surface. Expressed widely on macrophages it helps in the clearance of glycosylated antigens and pathogens that have been tagged for degradation. Anti-CD206 antibodies are commonly used in the study of macrophage biology helping to identify and isolate cells expressing the CD206 marker.
Pathways
Mannose receptor plays a significant role in the immune system's pathogen recognition and clearance pathways. It is involved in phagocytosis and antigen processing connecting with lysosomal enzymes following endocytosis of pathogens. This receptor’s function can interface with components of the toll-like receptor (TLR) pathways where it may work alongside proteins such as CD14 in recognizing pathogen-associated molecular patterns.
Mannose receptor is implicated in infectious diseases and inflammatory conditions. It is involved in the body's response to bacterial infections aiding in the phagocytosis and clearance of these pathogens. Its role in inflammation connects it with disorders such as atherosclerosis where dysfunctional macrophage activation can be observed. The mannose receptor interacts with other proteins related to these conditions including CD209 which also participates in pathogen recognition and immune response functionalities.