Abcam, ab64803, Anti-TUSC5 antibody

Size: 100µg
Rabbit Polyclonal TUSC5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TRARG1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRARG1. The exact immunogen used to generate this antibody is proprietary information.Q8IXB3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TUSC5 protein also known as Tumor Suppressor Candidate 5 plays specific mechanical roles in cellular function. It has a molecular mass of approximately 30 kDa. TUSC5 is expressed mostly in adipose tissue and peripheral nervous system tissues. Its structure includes four transmembrane domains making it a component of cell membranes where it can interact with other membrane-associated proteins.
Biological function summary
The TUSC5 protein interacts with cellular processes related to metabolism and cell growth regulation. While it is not part of a large defined protein complex its function influences energy homeostasis within adipocytes. TUSC5 regulates expression of genes involved in lipid metabolism providing key adjustments to adipocyte function. This regulation aids in the adaptation to changes in energy balance and nutrient availability within the organism.
Pathways
The TUSC5 protein participates in both lipid metabolism and insulin signaling pathways. It influences how adipocytes respond to insulin linking to proteins such as AKT1 which plays a prominent role in glucose uptake and metabolism. Insulin-mediated pathways which are critical to energy storage and release in adipose tissue also benefit from the regulatory influence of TUSC5 ensuring proper cellular response to hormonal signals.
TUSC5 impacts conditions like obesity and type 2 diabetes. These metabolic disorders result from an imbalance in energy intake and expenditure where TUSC5 plays a role in modulating fat storage and lipid metabolism. Research shows that aberrant expression of the TUSC5 protein correlates with disrupted metabolic homeostasis in adipose tissues. The protein is further linked to disorders through its relationship with AKT1 which is essential for maintaining normal insulin function and glucose homeostasis.