Abcam, ab65078, Anti-SND1 antibody

Size: 100µg
Rabbit Polyclonal SND1 antibody. Suitable for IP, WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 17 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Staphylococcal nuclease and Tudor domain-containing protein 1 (SND1) also known as Tudor-SN is a multifunctional protein with a molecular mass of approximately 100 kDa. SND1 acts as a coactivator in transcription and has nucleolytic activity tied to RNA processing and degradation. Researchers observe its wide expression in various tissues with higher levels in the liver brain and heart. Functionally significant SND1 binds to several molecules including double-stranded RNA which provides it with broad regulatory roles.
Biological function summary
SND1 engages in several cellular functions such as mRNA editing and splicing. It is a component of the RNA-induced silencing complex (RISC) which is essential in gene regulation through RNA interference. Within this complex SND1 interacts with other proteins and nucleic acids to contribute to post-transcriptional gene silencing. SND1 also influences transcriptional activation by interacting with transcription factors enhancing the expression of specific genes.
Pathways
SND1 plays roles in two important areas: RNA interference (RNAi) and lipid metabolism. In the RNAi pathway it facilitates gene silencing by being part of RISC collaborating with proteins such as Argonaute to mediate target mRNA degradation. In lipid metabolism SND1 interacts with proteins like sterol regulatory element-binding proteins (SREBPs) linking it to cholesterol homeostasis and fatty acid biosynthesis.
SND1 is linked to several cancer types including liver cancer and breast cancer. Its overexpression has been associated with tumor progression and poor prognosis in these conditions. SND1's interaction with oncogenic proteins such as Myc supports its role in cancer development. Additionally researchers have identified a connection between SND1 and Alzheimer's disease where it may influence neurodegenerative processes through interactions with amyloid precursor protein (APP) and other proteins involved in neuronal health.