Abcam, ab6509, Anti-HSV1 gC Envelope Protein antibody [3G9]

Size: 100µg
Mouse Monoclonal GC antibody. Suitable for WB, ICC/IF and reacts with Herpes simplex virus samples. Cited in 18 publications. Immunogen corresponding to Virus preparation containing HSV1 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:3G9,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Herpes simplex virus,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HSV1 gC envelope protein also known as glycoprotein C or gC-1 is a component of the herpes simplex virus type 1 (HSV1). This protein plays an important mechanical role in virus-host interactions. Glycoprotein C has a molecular mass of approximately 120 kDa and primarily expresses on the surface of the HSV1 virion envelope. It participates in viral attachment and penetration by binding to the host cell's heparan sulfate proteoglycans facilitating the initial stage of viral infection.
Biological function summary
The gC protein contributes to immune evasion and viral dissemination within the host. It participates in a complex with other viral envelope proteins to enhance the infectivity and stability of the viral particle. By interfering with the host's complement system gC aids the virus in evading immune recognition and destruction allowing prolongation of infection. It further modulates the interaction with immune cells impacting the body's ability to mount an effective immune response.
Pathways
The HSV1 gC envelope protein prominently functions within the viral entry and immune evasion pathways. It associates with other glycoproteins such as gB and gD in the viral envelope to mediate virus entry into host cells. HSV1 gC's function also intersects with complement regulatory proteins like factor H which the virus exploits to resist complement-mediated lysis. These pathways allow the virus to efficiently enter host cells and persist by avoiding immune neutralization.
HSV1 gC envelope protein links most notably to herpes simplex labialis commonly known as cold sores and herpes keratitis which affects the cornea. The gC protein contributes to pathogenesis by aiding viral spread and persistence in neural tissues leading to recurrent infections. It interacts with immune-related proteins such as complement components in the host exacerbating tissue inflammation and lesion formation during herpes simplex virus reactivation.