Abcam, ab6510, Anti-HSV1 gE Envelope Protein antibody [9H3]

Size: 100µg
Mouse Monoclonal GE antibody. Suitable for ELISA, WB, ICC/IF and reacts with Herpes simplex virus samples. Cited in 10 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:9H3,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Herpes simplex virus,
Applications:ELISA, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HSV1 gE Envelope Protein also known as glycoprotein E plays an important role in the lifecycle of herpes simplex virus type 1 (HSV-1). It consists of approximately 550 amino acids with a mass around 80 kDa. It is expressed on the surface of the viral envelope. HSV1 gE facilitates viral attachment and entry into host cells by mediating binding to cellular receptors. It is critical for virus-cell fusion necessary for viral dissemination in the host.
Biological function summary
This protein helps modulate the immune response by interacting with the host's immune factors. Glycoprotein E forms a complex with glycoprotein I (gI) assisting in immune evasion. This complex interferes with antibody-mediated neutralization and assists in transporting the virus along neurons. The gE/gI complex plays an important role in cell-to-cell spread enhancing viral propagation within the host organism.
Pathways
HSV1 gE participates in immunoevasion and virion assembly pathways important for HSV-1 infectivity. It interacts with specific host proteins to modulate the immune system's recognition of infected cells like the major histocompatibility complex (MHC) pathway. This interaction is notable with immune system receptors and proteins implicated in viral-host interplay.
The HSV1 gE Envelope Protein is particularly associated with herpes simplex virus-related conditions like cold sores and herpes encephalitis. The protein's ability to evade the immune response contributes to recurrent infections. During infection it interacts with other viral proteins such as HSV1 glycoprotein D which is involved in attachment to host cells and immune modulation exacerbating disease severity.