Abcam, ab66498, Anti-Neurogenin 1/NEUROG1 antibody

Size: 100µL
Rabbit Polyclonal Neurogenin 1/NEUROG1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human NEUROG1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NEUROG1. The exact immunogen used to generate this antibody is proprietary information.Q92886

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neurogenin 1 (NEUROG1) also known as neurogenin belongs to the family of basic helix-loop-helix (bHLH) transcription factors. The molecular mass of NEUROG1 is approximately 23 kilodaltons. This protein is mainly expressed in developing neural tissues where it plays an important role in the differentiation of neuronal precursor cells into mature neurons. NEUROG1 is strongly expressed in the central nervous system particularly during neurogenesis.
Biological function summary
The gene encoding NEUROG1 serves a critical function in the specification of neuronal identity. It acts as a transcriptional regulator guiding the assembly of cell-specific transcriptional complexes. NEUROG1 does not work alone; it interacts with other bHLH factors such as Mash1 to propagate neuronal differentiation signals. The protein is essential for initiating the cascade of neuronal gene expression programs that lead to the development of the nervous system.
Pathways
NEUROG1 participates in the neurogenic pathway particularly influencing the Notch signaling pathway and the Wnt signaling pathway. Within these pathways NEUROG1 cooperates with proteins like Delta-Notch and Wnt to regulate the balance between proliferation and differentiation in progenitor cells. This ensures proper neuronal patterning and development optimizing the formation and functionality of the nervous system.
NEUROG1 has links to certain neurodevelopmental disorders and neuronal damage. Mutations or misregulation of NEUROG1 can contribute to conditions such as autism spectrum disorder and epileptic syndromes. Its interaction with proteins such as Notch1 is significant as altered Notch signaling is often observed in these conditions highlighting the role of NEUROG1 in maintaining neural homeostasis and signaling integrity.