Abcam, ab66641, Anti-HIV1 p17 antibody [17-1]

Size: 100µL
Mouse Monoclonal POL antibody. Suitable for IP, Flow Cyt, WB, ICC/IF and reacts with Human immunodeficiency virus samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:17-1,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human immunodeficiency virus,
Applications:IP, Flow Cyt, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab66641 recognises bacterial HIV1 P17 Gag protein

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HIV1 p17 also known as matrix protein is a structural component of the Human Immunodeficiency Virus type 1 (HIV-1). It has a molecular mass of approximately 17 kDa. The protein is expressed in the virion as part of the gag polyprotein precursor. HIV1 p17 plays an important role in the initial assembly and budding of new virions by stabilizing the capsid structure. Its localization at the inner surface of the viral membrane assists in maintaining structural integrity ensuring successful viral replication and transmission.
Biological function summary
HIV1 p17 functions by interacting with the host cell's machinery playing a pivotal role in viral replication. The matrix domain of the HIV virus is not a functional standalone entity; it is part of the gag polyprotein complex that also includes capsid and nucleocapsid proteins. This complex facilitates the incorporation of viral RNA into forming virions ensuring the viral genome is packaged correctly for delivery into new host cells. HIV1 p17 contributes to this interaction by binding to host cell membranes a necessary step for the viral replication cycle.
Pathways
The HIV1 p17 protein engages in the HIV-1 life cycle pathway intimately associated with viral entry and assembly processes. It plays an essential role in the viral budding pathway driving the assembly and release of the virus from host cells. Notably p17 interacts with the host’s PI3K/Akt signaling pathway which is important for promoting cell survival and enhancing viral replication efficiency. Additionally it relates to the envelope glycoprotein gp120 that facilitates viral entry by binding to CD4 and co-receptors on host cells.
HIV1 p17 has a significant connection to Acquired Immunodeficiency Syndrome (AIDS) a condition resulting from the chronic infection with HIV. The protein's role in the assembly and stability of the virion directly influences the progression of HIV infection to AIDS. Researchers have observed p17’s involvement with overactive immune response implications possibly contributing to immunological disorders associated with HIV. Furthermore it interacts with the p24 protein another vital gag component which serves as a marker in the diagnosis and monitoring of HIV infection progression.