Abcam, ab67000, Anti-VIP36 antibody [264C4a]

Size: 100µg
Mouse Monoclonal VIP36 antibody. Suitable for WB and reacts with Recombinant fragment samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LMAN2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:264C4a,
Isotype:IgG2a,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LMAN2. The exact immunogen used to generate this antibody is proprietary information.Q12907

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
VIP36 also known as vesicular integral-membrane protein 36 operates as a lectin involved in glycoprotein transport within the cell. It has a mass of approximately 36 kDa. Scientists observe its expression mainly in the liver and testis where it localizes to the Golgi apparatus and endoplasmic reticulum. VIP36 functions to select specific N-linked glycans facilitating their sorting and transport essential for proper protein localization and function.
Biological function summary
Vesicular integral-membrane protein 36 contributes to the quality control of glycoproteins within the secretory pathway. While not forming part of a larger complex VIP36 plays a critical role in recognizing high-mannose-type glycoproteins which are critical for cell-cell communication and adhesion. This function helps maintain cellular homeostasis and impacts various cellular activities reflecting the protein's importance in cellular processes.
Pathways
Glycoprotein transport and sorting rely on VIP36 which interacts with pathways like the secretory pathway and vesicle trafficking. The protein impacts the dynamics of protein glycosylation fundamental for the correct functioning of proteins like E-cadherin. By ensuring glycoproteins reach their proper destinations within the cell VIP36 plays an important role in maintaining cellular architecture and facilitating important signaling processes.
Disruptions in VIP36 functionality might contribute to disorders like liver cirrhosis and testicular malfunction. Problems in its glycoprotein sorting capability can affect proteins such as alpha-fetoprotein potentially altering normal cellular function and leading to disease. Researchers continue to investigate VIP36's role in these disorders aiming to understand how alterations in this protein could offer insights into therapeutic targets.