Abcam, ab67225, Anti-Plxdc2 antibody

Size: 100µg
Rabbit Polyclonal Plxdc2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PLXDC2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PLXDC2. The exact immunogen used to generate this antibody is proprietary information.Q6UX71

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Plexin domain containing 2 (PLXDC2) also known as tumor endothelial marker 7 (TEM7) is a protein involved in cellular signaling. It has a molecular mass of approximately 65 kDa. PLXDC2 is significantly expressed in endothelial cells particularly within the vasculature where it may play a role in cell adhesion and migration processes. The expression of PLXDC2 has been observed in various tissues with notable presence in the brain and liver suggesting its importance in multiple physiological contexts.
Biological function summary
PLXDC2 functions as part of the extracellular matrix (ECM) interaction network. It potentially contributes to angiogenesis and vascular remodeling by influencing endothelial cell behavior. While not a classic receptor PLXDC2 interacts with other ECM components and cell surface molecules to support cellular communication and interaction. These activities highlight its involvement in dynamic vascular processes and possibly in tissue homeostasis and repair mechanisms.
Pathways
PLXDC2 participates in pathways related to the regulation of angiogenesis and ECM remodeling. It shows connections to the vascular endothelial growth factor (VEGF) pathway which is integral to promoting new blood vessel formation. Additionally PLXDC2 is associated with integrins which facilitate ECM interactions and influence cell movement and signaling. This involvement indicates PLXDC2's contributory role in maintaining vascular integrity and supporting tissue regeneration.
PLXDC2's aberrant expression links to cancer progression and possibly metastasis. Its expression levels have shown correlation with tumors particularly in their angiogenic regions indicating a potential role in tumor growth and vascularization. PLXDC2 association with VEGF implicates it in oncological conditions including various types of cancer where angiogenesis is a critical factor. Understanding PLXDC2's role in these contexts can offer insights into new therapeutic strategies targeting tumor vasculature.