Abcam, ab67270, Anti-DHX58/RLR antibody

Size: 100µg
Rabbit Polyclonal DHX58/RLR antibody. Suitable for WB and reacts with Rat samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DHX58 also known as LGP2 is a member of the RIG-I-like receptor (RLR) family. It has an important role in the immune response against viral infections. This protein weighs approximately 73 kDa. DHX58 lacks the caspase activation and recruitment domains found in other RLRs which distinguishes its function. It expresses in multiple tissues including the spleen and peripheral blood leukocytes where it contributes to the detection of viral RNA.
Biological function summary
DHX58 functions as a regulatory molecule in innate immunity. It usually does not act alone and can form complexes with other RLRs like RIG-I and MDA5. These complexes enhance antiviral signal transduction by modulating downstream components of the interferon signaling pathway. By influencing these pathways DHX58 contributes to the regulation of the immune response ensuring the proper activation of antiviral defense mechanisms.
Pathways
Several immune pathways involve DHX58 namely the RIG-I-like receptor signaling pathway and the interferon regulatory pathways. These pathways are critical for maintaining the body's defense against viral infections. Within these pathways DHX58 interacts with related proteins such as RIG-I and MDA5 which are important for recognizing viral RNA and facilitating subsequent immune responses.
Research suggests that alterations in DHX58 function can link to autoimmune disorders such as systemic lupus erythematosus (SLE) and viral infections. The target's proper regulation is essential to prevent inappropriate immune activation which might lead to such conditions. In these contexts proteins like RIG-I and MDA5 frequently interact with DHX58 influencing the disease outcomes and severity.