Abcam, ab67721, Anti-ABLIM3 antibody

Size: 50µg
Mouse Polyclonal ABLIM3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ABLIM3.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ABLIM3.O94929

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABLIM3 short for Actin Binding LIM protein 3 is a target with a mass of approximately 75 kDa. This protein contains several LIM domains and primarily binds with actin filaments. It functions as an adaptor facilitating cytoskeletal dynamics and signal transmissions. You find ABLIM3 expressed in various tissues including central nervous tissue and muscles which indicates its broad role in maintaining cellular framework and functions.
Biological function summary
ABLIM3 plays a critical role in cell shape and motility by connecting actin filaments with signal transduction pathways. This protein associates with the cytoskeleton and influences changes in actin organization. It often works as part of a protein complex that includes LIM domain proteins which modulate actin cytoskeleton stability and cell signaling. These interactions highlight its importance in controlling cellular responses to extracellular signals.
Pathways
ABLIM3 is integral to pathways related to cell motility and cytoskeletal organization. It contributes to the arrangement of actin filaments affecting cell migration and adhesion processes. In particular ABLIM3 interacts with proteins like integrins and vinculin in these pathways coordinating changes necessary for cellular movement and structure. These associations support cellular architecture and movement adaptations.
Abnormal expressions of ABLIM3 relate to certain cancers and neurological disorders. In cancer especially in metastatic diseases disruptions in ABLIM3-mediated signaling can lead to altered cell motility promoting tumor growth and spread. For neurological disorders ABLIM3 connections with proteins such as actin-related proteins may contribute to pathologies involving synaptic stability and neurodegeneration. These links illustrate the significant impact of ABLIM3 in health and disease contexts.